Metallocene-based chiral phosphine or arsine ligands
US7994355B2 · kind B2 · utility
1Cited by
8References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 2005 |
| Grant date | Aug 9, 2011 |
| Priority date | — |
| Expiry date | Apr 3, 2027 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/847
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compounds. A method for the preparation of ligands according to the invention involving the conversion of the ortho-lithiated substituted metallocene to a phosphine chiral at phosphorus is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.