Crystalline forms of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

US7994364B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Andreas Fischer · Castro Valley, US
• Helmut Buschmann · Walheim, DE
• Michael Gruss · Aachen, DE
• Dagmar Lischke · Eschweiler, DE

Key dates

• Filing date: Dec 10, 2009
• Grant date: Aug 9, 2011
• Expiry date: Dec 10, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A hitherto unknown crystalline form of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.