Diagnosis and therapy of antibody-mediated inflammatory auto-immune disorders
US7998681B2 · kind B2 · utility
2Cited by
3References
6Claims
0Family size
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Key dates
| Filing date | Jan 3, 2002 |
| Grant date | Aug 16, 2011 |
| Priority date | — |
| Expiry date | Jul 14, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic molecular markers and antibody-mediated ligand-receptor interactions. Specifically, the activation of T-cells by disease specific IgG binding to the IGF-1 receptor is shown to underlie thyroid associated ophthalmopathy associated with Graves' disease and rheumatoid arthritis. Diagnostics for detection of disease are provided, as are therapeutics based on the determination of the mechanisms underlying a particular pathology.
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