RNA aptamers and the uses thereof
US7999089B1 · kind B1 · utility
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7Claims
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Assignee
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Key dates
| Filing date | Oct 9, 2006 |
| Grant date | Aug 16, 2011 |
| Priority date | — |
| Expiry date | Oct 2, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to RNA aptamers and uses thereof, more precisely RNA aptamers interfering the interaction of TCF with other proteins by binding specifically to β-catenin, RNA aptamers binding specifically to HMG domains of TCF-I proteins and uses of the same. The RNA aptamer of the present invention can be effectively used for the development of an anticancer agent since it binds specifically to TCF-I to interrupt the interaction of TCF with β-catenin involved in tumorigenesis and metastasis and the transcriptional activity of TCF-I in relation to oncogenes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.