Mutant PCNA
US8003346B2 · kind B2 · utility
5Cited by
4References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 4, 2006 |
| Grant date | Aug 23, 2011 |
| Priority date | — |
| Expiry date | Jan 10, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/69
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.