Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH
US8003356B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Apr 13, 2005 |
| Grant date | Aug 23, 2011 |
| Priority date | — |
| Expiry date | Apr 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/40
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.