Patent · US Active

Method for creating perfusable microvessel systems

US8003388B2 · kind B2 · utility

0Cited by

7References

12Claims

0Family size

Assignee

NORTIS, INC. · US

Inventor

Thomas Neumann · Munich, DE

Key dates

Filing date	Sep 24, 2007
Grant date	Aug 23, 2011
Priority date	—
Expiry date	Mar 28, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/50
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for creating networks of perfusable microvessels in vitro. A mandrel is drawn through a matrix to form a channel through the matrix. Cells are injected into the channel. The matrix is incubated to allow the cells to attach inside the channel. The channel is perfused to remove unattached cells to create a parent vessel, where the parent vessel includes a perfusable hollow channel lined with cells in the matrix. The parent vessel is induced to create sprouts into the surrounding matrix gel so as to form a microvessel network. The microvessel network is subjected to luminal perfusion through the parent vessel.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.