Patent · US Active

NT-proBNP/troponin ratio for assessing myocardial dysfunction

US8003396B2 · kind B2 · utility

7Cited by

1References

11Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Georg Hess · Mainz, DE
Andrea Horsch · Luzern, CH
Dietmar Zdunek · Tutzing, DE

Key dates

Filing date	Mar 29, 2010
Grant date	Aug 23, 2011
Priority date	—
Expiry date	Mar 29, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/325
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method of diagnosing if a subject which has suffered from an acute myocardial infarction is also suffering from a pre-existing myocardial dysfunction, the method comprising a) determining the amount of a natriuretic peptide in a sample of the subject; b) determining the amount of a cardiac troponin in a sample of the subject; c) calculating the ratio (natriuretic peptide/cardiac troponin); and d) diagnosing if the elevated natriuretic peptide level is related to a preexisting myocardial dysfunction or if the elevated level is caused by the acute myocardial infarction, based on the ratio calculated in step c). The method allows determining whether the individual has suffered from a myocardial dysfunction, in particular heart failure, before the myocardial infarction has occurred.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.