HGF precursor protein variant and active protein thereof
US8003607B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Mar 30, 2007 |
| Grant date | Aug 23, 2011 |
| Priority date | — |
| Expiry date | May 9, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.