Analogs of benzoquinone-containing ansamycins and methods of use thereof
US8003634B2 · kind B2 · utility
2Cited by
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33Claims
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Key dates
| Filing date | Oct 6, 2010 |
| Grant date | Aug 23, 2011 |
| Priority date | — |
| Expiry date | Oct 6, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.