Heterocyclic GPR40 modulators

US8003648B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Hilary Plake Beck · Emerald Hills, US
• Paul John Dransfield · Arlington, US
• Zice Fu · Foster City, US
• Jonathan Houze · Cambridge, US
• XianYun Jiao · Belmont, US
• Todd J. Kohn · Thousand Oaks, US
• SuJen Lai · Burlingame, US
• Jinqian Liu · Palo Alto, US
• Jiwen Liu · Winston-Salem, US
• Zhihua Ma · Lexington, US
• Julio C. Medina · Redwood City, US
• Michael J. Schmitt · San Francisco, US
• Rajiv Sharma · Mumbai, IN
• Wang Shen · San Mateo, US
• Marc Vimolratana · New York, US
• Yingcai Wang · Millbrae, US
• Zhongyu Wang · Nanjing, CN

Key dates

• Filing date: Nov 5, 2009
• Grant date: Aug 23, 2011
• Expiry date: Nov 10, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.