Daptomycin for the treatment of biofilm and catheter salvage

US8003673B2 · kind B2 · utility

Assignee

• Cubist Pharmaceuticals LLC · US

Inventors

• Jeffrey Douglas Alder · Harvard, US
• Jared Silverman · Brookline, US
• Lawrence Mortin · Framingham, US
• Andrew Van Praagh · Chelmsford, US

Key dates

• Filing date: May 31, 2006
• Grant date: Aug 23, 2011
• Expiry date: Sep 4, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Daptomycin can be used for biofilm treatment (particularly central venous catheter salvage for S. epidermidis infected catheters). Catheter salvage with daptomycin shows rapid cidality, activity against stationary phase bacteria, and penetration and activity in biofilms. The present inventions provide formulations, methods, and articles of manufacture useful for biofilm treatment or catheter salvage involving daptomycin. Particular formulations include daptomycin in lactated Ringer's solution having a rapid kill curve against the bacteria of the biofilm.