Compounds and compositions for reducing lipid levels

US8003795B2 · kind B2 · utility

Assignee

• CVI Pharmaceuticals Limited · KY

Inventors

• Haiyan Liu · Beijing, CN
• Junbo Wang · Baofeng County, CN
• Rui Zhang · Plainsboro, US
• Nicholas Cairns · Los Altos, US
• Jingwen Liu · Zhejiang, CN

Key dates

• Filing date: Jun 20, 2008
• Grant date: Aug 23, 2011
• Expiry date: Jun 2, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D455/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions comprising extracts or isolated or purified compounds from plants of the genus Corydalis provide prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Corydalis compounds and their derivatives of natural and synthetic origins lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression and activate AMP-activated protein kinase. Specific stereoisomers of Corydalis compounds with lipid lowering activity include 14R-(+)-corypalmine, 14R,13S-(+)-corydaline, 14R-(+)-tetrahydropalmatin, (+)-corlumidin, d-(+)-bicuculline, and (+)-egenine.