Protein crystallization screening and optimization droplet actuators, systems and methods
US8007739B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 16, 2007 |
| Grant date | Aug 30, 2011 |
| Priority date | — |
| Expiry date | Mar 9, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2575
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Protein crystallization screening and optimization droplet actuators, systems and methods are provided. According to one embodiment, a screening droplet actuator is provided and includes: (a) a port for introduction of one or more crystallization reagents and/or one or more protein solutions; and (b) a substrate including: (i) an array of two or more mixing wells; and (ii) electric field mediated microfluidics for moving droplets comprising the crystallization reagents and protein solutions into the mixing wells. Optimization droplet actuators, systems including screening droplet actuators, methods of screening protein crystallization conditions, and methods of testing conditions for growing a crystal are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.