Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
US8007823B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2004 |
| Grant date | Aug 30, 2011 |
| Priority date | — |
| Expiry date | Feb 17, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/58
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers are melt-blended, thereby preparing a polymer blend, wherein said polymers A and B have an essentially continuous morphology. Thirdly, after cooling, polymer B and compatibilizer C are selectively extracted from the polymer blend by dissolution in a solvent that is a non-solvent of polymer A. The resulting polymeric article has an essentially continuous porosity with a void volume between 10 and 90% and a unimodal diameter distribution set to a predefined unimodal peak location. It can be used in tissue engineering, for controlled release applications or as an implantable medical device.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.