Loading of hydrophobic drugs into hydrophilic polymer delivery systems
US8007831B2 · kind B2 · utility
11Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 9, 2007 |
| Grant date | Aug 30, 2011 |
| Priority date | — |
| Expiry date | Jan 18, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.