Patent · US Active

Methods to identify protein arginine deiminase 4 inhibitors

US8007996B2 · kind B2 · utility

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4Claims

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Assignee

UNIVERSITY OF SOUTH CAROLINA · US

Inventors

Paul R. Thompson · Columbia, US
Bryan Knuckley · Jacksonville, US

Key dates

Filing date	Oct 31, 2008
Grant date	Aug 30, 2011
Priority date	—
Expiry date	Jun 17, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/34
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.