Patent · US Active

Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid methyl ester sulfate by lipase acylation of racemic 4-(1-aminoethyl) benzoic acid methyl ester and sulfuric acid precipitation

US8008062B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignee

BASF SE

Inventors

Klaus Ditrich · Neheim, DE
Harald Winsel · Birkenheide, DE
Dominique Moulin · Bolbec, FR

Key dates

Filing date	Dec 19, 2006
Grant date	Aug 30, 2011
Priority date	—
Expiry date	Oct 14, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/07
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.