Macrocyclic inhibitors of hepatitis C virus

US8008251B2 · kind B2 · utility

Assignees

• Tibotec Pharmaceuticals Ltd. · IE
• MEDIVIR AB · SE

Inventors

• Kenneth Alan Simmen · Tervuren, BE
• Herman Augustinus De Kock · Arendonk, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE
• Mats Stefan Lindström · Huddinge, SE
• Pia Kahnberg · Huddinge, SE
• Dmitry Antonov · Huddinge, SE
• Karl Magnus Nilsson · Vimmerby, SE
• Bengt Bertil Samuelsson · Skärholmen, SE
• Asa Annica Kristina Rosenquist · Huddinge, SE

Key dates

• Filing date: Jul 28, 2006
• Grant date: Aug 30, 2011
• Expiry date: Jun 19, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HCV of formula (I).and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6;pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.