Methods and compositions for enhanced transmucosal delivery of peptides and proteins
US8008255B2 · kind B2 · utility
18Cited by
26References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 28, 2004 |
| Grant date | Aug 30, 2011 |
| Priority date | — |
| Expiry date | Sep 30, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides compositions for enhancing the transmucosal absorption of bioactive peptides and proteins, such as exendin-4, PYY, PYY3-36, and GLP-1 and their analogs and derivatives, wherein the compositions comprise an absorption enhancing mixture of a cationic polyamino acid and a buffer that is compatible with the polyamino acid. Also provided are methods for enhancing the transmucosal absorption and bioavailability of bioactive peptides and proteins using such compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.