Treatment of colorectal polyps with imidazoquinoline derivatives

US8008319B2 · kind B2 · utility

Assignee

• MEDA PHARMA GMBH & CO. KG · DE

Inventors

• Joachim Maus · Mühlheim, DE
• Istvan Szelenyi · Arnstorf, DE
• Ursula Petzold · Emmelshausen, DE

Key dates

• Filing date: Jan 14, 2009
• Grant date: Aug 30, 2011
• Expiry date: Mar 8, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to treating colorectal polyps and precancercerous colorectal changes by topical administration of immunomodulating drugs of the imidazoquinoline family, such as imiquimod (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine), resiquimod (4-amino-α,α-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol), sotirimod (2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine).