Plasma carboxypeptidase B inhibitors

US8008325B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Brad O. Buckman · Oakland, US
• Kumar Emayan · Berkeley, US
• Imadul Islam · Hercules, US
• Karen May · Napa, US
• Judi Bryant · Mill Valley, US
• Raju Mohan · Encinitas, US
• Christopher William West · El Sobrante, US
• Shendong Yuan · San Ramon, US

Key dates

• Filing date: Dec 11, 2008
• Grant date: Aug 30, 2011
• Expiry date: Dec 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6524
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the following formula (I), for example:wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.