Adenovirus 36 E4 orf 1 gene and protein and their uses

US8008436B2 · kind B2 · utility

Assignees

• Wayne State University · US
• Board of Sup. of LSU and Agr. & Mechanical College · US

Inventors

• Nikhil V. Dhurandhar · Madison, US
• Thomas C. Holland · Ann Arbor, US
• Zhong Wang · Nanhu, CN

Key dates

• Filing date: Nov 30, 2006
• Grant date: Aug 30, 2011
• Expiry date: Dec 9, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/10332
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.