Substituted AZA-indoles as inhibitors of poly(ADP-ribose) polymerase (PARP)

US8008491B2 · kind B2 · utility

Assignee

• Aventis Pharmaceuticals Inc. · US

Inventors

• John Ziqi Jiang · Fryeburg, US
• Jack Roger Koehl · Whitehouse Station, US
• Shujaath Mehdi · Manville, US
• Neil Moorcroft · Bloomsbury, US
• Kwon Yon Musick · Raritan, US
• Philip M. Weintraub · Cincinnati, US
• Paul Robert Eastwood · Romford, GB

Key dates

• Filing date: Jun 17, 2008
• Grant date: Aug 30, 2011
• Expiry date: Oct 23, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a series of substituted aza-indole derivatives of the formula I:wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.