Tricyclic antibiotics

US8012961B2 · kind B2 · utility

Assignee

• Actelion Pharmaceuticals Ltd. · CH

Inventors

• Christian Hubschwerlen · Durmenach, FR
• Georg Rueedi · Allschwil, CH
• John-Philippe Surivet · Kembs, FR
• Cornelia Zumbrunn-Acklin · Basel, CH

Key dates

• Filing date: Apr 14, 2009
• Grant date: Sep 6, 2011
• Expiry date: Apr 14, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to antibacterial compounds of formula (I)wherein wherein R2 represents H, F or hydroxymethyl, and B is absent; wherein Y1, Y2, Y3 and Z independently represent CH or N; Q represents O or S; and E represents phenyl which is mono- or di-substituted wherein the substituents are each independently halogen;