Substituted pyrimidine compounds and their utility as CETP inhibitors

US8012989B2 · kind B2 · utility

Assignee

• KOWA COMPANY, LTD. · JP

Inventors

• Tadaaki Ohgiya · Tokorozawa, JP
• Toru Miura · Higashimurayama, JP
• Ayumu Okuda · Higashimurayama, JP
• Toshiharu Arai
• Koichi Yamazaki · Tokyo, JP
• Taro Aoki · Tokorozawa, JP
• Katsutoshi Miyosawa · Higashimurayama, JP
• Haruki Shibata · Tokyo, JP
• Kimiyuki Shibuya · Saitama, JP

Key dates

• Filing date: Jun 15, 2010
• Grant date: Sep 6, 2011
• Expiry date: Jun 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).