Kit for proximity probing with multivalent proximity probes
US8013134B2 · kind B2 · utility
39Cited by
4References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 22, 2002 |
| Grant date | Sep 6, 2011 |
| Priority date | — |
| Expiry date | Oct 6, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to sensitive, rapid and convenient assays for detection and or quantification of one or more analyte(s) in solution using multivalent proximity probes. The proximity probes each comprise several binding moieties, such as antibodies, and associated nucleic acid(s). When the binding moieties have bound to their analyte(s), the nucleic acids on opposite proximity probes interact with each other and a signal is generated based on this interaction. The multivalent proximity probes are especially valuable for highly sensitive and specific protein detection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.