Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage

US8013170B2 · kind B2 · utility

Inventors

• Paul William Richard Harris · Richmond, US
• Margaret Anne Brimble · Hamilton, NZ

Key dates

• Filing date: Dec 14, 2007
• Grant date: Sep 6, 2011
• Expiry date: Mar 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroacetate. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or neuronal cell death caused by in embodiments, toxicity or hypoxia. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.