Patent · US Active

Paricalcitol purification

US8013176B2 · kind B2 · utility

0Cited by

3References

4Claims

0Family size

Assignee

Alphora Research Inc. · CA

Inventors

Fabio Souza · Mississauga, CA
Ming Pan · Mississauga, CA
Kathleen Da Silva Turcot · Toronto, CA

Key dates

Filing date	Aug 19, 2009
Grant date	Sep 6, 2011
Priority date	—
Expiry date	Aug 19, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C401/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying. Isopropyl acetate appears to be unique among commonly available and pharmaceutically acceptable solvents in its ability to precipitate paricalcitol in this high purity, essentially free of isomers thereof. In addition, paricalcitol of purity of at least 99.9% has been shown to have exceptional storage stability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.