Influenza immunogen and vaccine
US8017127B2 · kind B2 · utility
6Cited by
28References
37Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 24, 2006 |
| Grant date | Sep 13, 2011 |
| Priority date | — |
| Expiry date | Nov 18, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.