Substituted, non-coding nucleic acid molecule for therapeutic and prophylactic stimulation of the immune system in humans and higher animals

US8017591B2 · kind B2 · utility

Assignee

• Mològen AG · DE

Inventors

• Bernadette Brzezicha · Berlin, DE
• Christiane Juhls · Berlin, DE
• Florian Sack · Berlin, DE
• Manuel Schmidt · Berlin, DE
• Burghardt Wittig · Berlin, DE
• Matthias Schroff · Berlin, DE

Key dates

• Filing date: Aug 18, 2006
• Grant date: Sep 13, 2011
• Expiry date: May 18, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Short deoxyribonucleic acid molecules that are partially single-stranded, dumbbell shaped, and covalently closed, which contain one or more unmethylated cytosine guanosine motif (CpG motif) and exhibit immunomodifying effects. Such molecules can be used for immunostimulation applications in humans and vertebrates.