Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment
US8017640B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Feb 27, 2007 |
| Grant date | Sep 13, 2011 |
| Priority date | — |
| Expiry date | May 17, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which C is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumors. The prodrug is expected to be activated preferentially in tumor cells, which it will act as a DNA alkylating agent preventing cell division.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.