Process for preparing acyclic HCV protease inhibitors

US8017771B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Carl Alan Busacca · Poughkeepsie, US
• Rogelio P. Frutos · Sandy Hook, US
• Nizar Haddad · Danbury, US
• Suresh R. Kapadia · Danbury, US
• Jon Lorenz · New Milford, US
• Anjan Saha · Hamden, US
• Chris Hugh Senanayake · Brookfield, US
• Xudong Wei · West Greenwich, US

Key dates

• Filing date: Jan 16, 2009
• Grant date: Sep 13, 2011
• Expiry date: Mar 12, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection:The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula:and halogenated or sulfonated bromoquinoline compounds.