Hydroxyphenyl cross-linked macromolecular network and applications thereof

US8021350B2 · kind B2 · utility

Assignee

• The Cleveland Clinic Foundation · US

Inventors

• Anthony Calabro · Upper Darby, US
• Aniq Darr · Lowerre, US
• Kiyotaka Fukamachi · Cleveland, US
• Richard A. Gross · Plainview, US
• Keiji Kamohara · Mayfield Heights, US
• Michael K. Banbury · Rockland, US

Key dates

• Filing date: Jan 29, 2009
• Grant date: Sep 20, 2011
• Expiry date: Jan 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.