Oral solid dosage forms containing a low dose of estradiol

US8022053B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Kristina Mueller · Berlin, DE
• Torsten Wagner · Wiesbaden, DE
• Adrian Funke · Berlin, DE
• Christian Zurth · Berlin, DE

Key dates

• Filing date: Nov 1, 2005
• Grant date: Sep 20, 2011
• Expiry date: Aug 14, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.