CRTH2 receptor ligands for medicinal uses

US8022063B2 · kind B2 · utility

Assignee

• 7TM Pharma A/S · DK

Inventors

• Trond Ulven · Odense, DK
• Thomas Frimurer · Copenhagen, DK
• Øystein Rist · Hørsholm, DK
• Evi Kostenis · Bonn, DE
• Thomas Hogberg · Gately Drive, SE
• Jean-Marie Receveur · Montpellier, FR
• Marie Grimstrup · Hørsholm, DK

Key dates

• Filing date: May 30, 2005
• Grant date: Sep 20, 2011
• Expiry date: Mar 23, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis, wherein A represents a carboxyl group —COON, or a carboxyl bioisostere; A1, is hydrogen or methyl; ring Ar1 is an optionally substituted phenyl ring 5- or 6-membered monocyclic heteroaryl ring, in which AA1CHO— and L2 are linked to adjacent ring atoms; rings Are2, Ar3 each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; t is 0 or 1; L2 and L3 are linker radicals as defined in the description.