Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof

US8022216B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Qinghong Lu · Suffern, US
• Mannching Sherry Ku · Thiells, US
• Warren Chew · ᐙᔂᓂᐲ Waswanipi, CA
• Gloria Cheal · Beaconsfield, CA
• Anthony F. Hadfield · Ruskin, US
• Mahmoud Mirmehrabi · Halifax, CA

Key dates

• Filing date: Oct 15, 2008
• Grant date: Sep 20, 2011
• Expiry date: Feb 19, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C57/145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.