Method for manufacture of escitalopram

US8022232B2 · kind B2 · utility

Assignee

• H. LUNDBECK A/S · DK

Inventors

• Carla De Faveri · Isola di Terranegra, IT
• Florian Huber · Grassau, DE
• Robert Dancer · Copenhagen, DK

Key dates

• Filing date: Sep 2, 2008
• Grant date: Sep 20, 2011
• Expiry date: May 9, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C253/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallizing 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)- or (−)-(R,R)-enantiomer of O,O′-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.