Protofibril selective antibodies and the use thereof

US8025878B2 · kind B2 · utility

Assignee

• BioArctic Neruoscience AB · SE

Inventors

• Pär Gellerfors · Lidingö, SE
• Lars Lannfelt · Stockholm, SE
• Dag Sehlin · Uppsala, SE
• Frida Ekholm Pettersson · Uppsala, SE
• Hillevi Englund · Uppsala, SE

Key dates

• Filing date: Mar 23, 2007
• Grant date: Sep 27, 2011
• Expiry date: Mar 23, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/387
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(C1q) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.