Patent · US Active

Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids

US8026089B2 · kind B2 · utility

0Cited by

23References

17Claims

0Family size

Assignee

E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

Howard Glenn Damude
Hongxian He · Wilmington, US
Der-Ing Liao · Wilmington, US
Quinn Qun Zhu · West Chester, US

Key dates

Filing date	Mar 18, 2010
Grant date	Sep 27, 2011
Priority date	—
Expiry date	Mar 18, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/0083
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.