Methods for inhibiting neoproliferative changes in blood vessel walls

US8026263B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Ralf Koehler · Hannover, DE
• Heike Wulff · Davis, US
• Joachim Hoyer · Marburg, DE
• K. George Chandy · Laguna Beach, US

Key dates

• Filing date: Oct 30, 2003
• Grant date: Sep 27, 2011
• Expiry date: Apr 29, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods, compositions and devices for inhibiting neoproliferative changes in blood vessel walls or other anatomical structures. One or more compounds of Formula I or I-A set forth herein are administered systemically and/or locally to human or veterinary patients to deter or prevent unwanted proliferative changes in blood vessels or other anatomical structures. The invention may be used to deter or prevent stenosis or restenosis of arteries following angioplasty and/or stent placement. In one embodiment, there is provided an implantable stent or stent graft from which one or more compounds of the present invention will elute or otherwise be delivered into an affected blood vessel wall.