Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors
US8026265B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Dec 21, 2006 |
| Grant date | Sep 27, 2011 |
| Priority date | — |
| Expiry date | Mar 13, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.