Transition metal catalyzed synthesis of N-aminoindoles

US8026375B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Nis Halland · Frankfurt am Main, DE
• Marc Nazare · Idstein, DE
• Andreas Lindenschmidt · Bad Soden, DE
• Omar Rkyek · Tangier, MA
• Matthias Urmann · Eschborn, DE
• Jorge Alonso · Mannheim, DE

Key dates

• Filing date: Oct 9, 2009
• Grant date: Sep 27, 2011
• Expiry date: Oct 9, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the regioselective synthesis of compounds of the formula I,wherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.