Process for the synthesis of anti-neoplasia agent VNP40101M
US8026395B1 · kind B1 · utility
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11Claims
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Key dates
| Filing date | May 27, 2009 |
| Grant date | Sep 27, 2011 |
| Priority date | — |
| Expiry date | Mar 27, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C303/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.