SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

US8029765B2 · kind B2 · utility

Assignee

• MASIMO LABORATORIES, INC. · US

Inventors

• Emile Bellott · Beverly, US
• Dongsheng Bu · Piscataway, US
• James J. Childs · Bolton, US
• Christopher R. Lambert · Hudson, US
• Hubert A. Nienaber · Worcester, US
• Shirley J. Shi · Lexington, US
• Zhaolin Wang · Wellesley, US
• Jerome J. Workman, Jr. · Appleton, US
• Alex Zelenchuk · Stoughton, US

Key dates

• Filing date: Dec 23, 2004
• Grant date: Oct 4, 2011
• Expiry date: Jun 20, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/144444
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.