Fluorescent membrane intercalating probes and methods for their use
US8029767B2 · kind B2 · utility
2Cited by
10References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 8, 2008 |
| Grant date | Oct 4, 2011 |
| Priority date | — |
| Expiry date | Oct 7, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B23/086
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.