Oligonucleotide and use thereof
US8030289B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Aug 6, 2008 |
| Grant date | Oct 4, 2011 |
| Priority date | — |
| Expiry date | Jan 27, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/17
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An oligonucleotide with a nucleotide sequence of 5′-cctcctcctcctcctcctcctcct-3′ (SEQ ID NO: 1) inhibits proliferation of human PBMC activated by TLR9 agonist and interferon production from human PBMC induced by TLR9 agonist, HSV-1, flu virus and serum from SLE patients, and rescues the mice from cytokine-mediated lethal shock. This oligonucleotide can be used as a remedy for the treatment of systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes and other immune-mediated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.