Antisense antiviral compounds and methods for treating a filovirus infection
US8030292B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 11, 2009 |
| Grant date | Oct 4, 2011 |
| Priority date | — |
| Expiry date | Apr 1, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3513
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the Ebola virus AUG start site region of VP24; ii) the Ebola virus AUG start site region of VP35; iii) the Marburg virus AUG start site region of VP24; or iv) the Marburg virus AUG start site region of NP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.