Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders

US8030297B2 · kind B2 · utility

Assignees

• OTONOMY, INC. · US
• The Regents of the University of California · US

Inventors

• Jay Lichter · Rancho Santa Fe, US
• Andrew M. Trammel · Olathe, US
• Jeffrey P. Harris · Village of La Jolla, US
• Fabrice Piu · San Diego, US
• Carl Lebel · Malibu, US
• Qiang Ye · San Diego, US
• Luis A. Dellamary · San Marcos, US

Key dates

• Filing date: May 14, 2009
• Grant date: Oct 4, 2011
• Expiry date: Sep 1, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).