Biosynthetic gene cluster for the production of a complex polyketide

US8030325B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Min He · Dongguan, CN
• John Hucul · New City, US
• Bradley Arnold Haltli · Monsey, US
• Melissa M. Wagenaar · Middletown, US
• Edmund Idris Graziani · Chestnut Ridge, US
• Mia Summers · Nyack, US
• Kerry Kulowski · Ringwood, US
• Kevin Pong · Lawrence, US
• Xidong Feng · Fair Lawn, US

Key dates

• Filing date: Jul 25, 2008
• Grant date: Oct 4, 2011
• Expiry date: Dec 12, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.